Reactive oxygen species-dependent regulation of pyruvate dehydrogenase kinase-4 in white adipose tissue
نویسندگان
چکیده
منابع مشابه
Pyruvate Dehydrogenase Kinase 4
OBJECTIVE Pyruvate dehydrogenase complex (PDC) serves as the metabolic switch between glucose and fatty acid utilization. PDC activity is inhibited by PDC kinase (PDK). PDC shares the same substrate, i.e., pyruvate, as glyceroneogenesis, a pathway controlling fatty acid release from white adipose tissue (WAT). Thiazolidinediones activate glyceroneogenesis. We studied the regulation by rosiglita...
متن کاملPDK4 in adipocyte glyceroneogenesis Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2020
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00313.2019